This Symposium focuses on the synthesis, characterization, and performance (both in vitro and in vivo) of coatings and modified surfaces designed for biomedical applications (biomaterials, bioimplants, biosensors, general health care, etc.). The symposium will be devoted to creating a platform, a friendly hub, to promote research discussions between material scientists, coating experts, and clinicians. Papers are solicited in areas related to bioactive and biocompatible coatings for implants (orthopedic, dental, spinal, etc.), cardio-vascular stents, drug delivery, biosensing. Examples of research topics sought are hydroxyapatite coatings, biomimetic and bio-inspired coatings, antimicrobial, anti-biofouling, drug-eluting coatings, blood-compatible coatings, electrospun coatings, biofunctionalization of materials surfaces such as tissue engineering scaffolds by wet chemical and plasma methods, cell-surface interactions, bio-lubrication and bio-tribology, and processing and characterization of biomaterial surfaces. Studies of the interactions between coatings and the biological environment, including tribocorrosion and other degradation mechanisms are also welcome. Moreover, research on the effect of biomaterial coatings on biological behavior, such as cell growth, adhesion, and gene expression are sought. Contributions in the fields of retrieval implant analysis, the release of metal ions/particles, smart/intelligent surfaces and potential clinical concerns will be also considered. A new key interest is applications of coatings in additive manufacturing, as many novel 3D-printed implants benefit from surface coatings to promote osseointegration and more generally biocompatibility.
D1. Surface Coating and Surface Modification in Biological Environments
This session is dedicated to coatings as well as surface modifications for use in biomedical applications in order to improve performance characteristics or to add functionality to an implant or surgical instrument. The functions of these coatings/surface modifications may focus on the improvement of one or more attributes such as biocompatibility, cell proliferation, and viability, suppression of restenosis, preventing thrombus formation, antimicrobial properties, controlling metallic ion release, resisting corrosion and wear, etc. under in vitro and in vivo conditions.
D1 Invited Speakers:
- Jayaraman Balamurugan, Korea Advanced Institute of Science & Technology (KAIST), Republic of Korea, “Current status and New directions of Using Electrochemistry for Health care Innovation”
- Nandini Duraiswamy, U.S. Food and Drug Administration, USA, “Updates on the Coatings on the Guidewires in Cardio-Interventional Procedures”
- Peter Apata Olubambi, University of Johannesburg, South Africa, “Nano-Mechanical Titanium Coating”
D2. Medical Devices: Bio-Tribo-Corrosion, Diagnostics, 3D Printing
Metallurgical materials are essential components of medical devices used to restore biological function, detect or respond to physiological or external stimuli, or modulate the response of cells at interfaces. This session seeks to explore clinical applications and physiological responses to material systems used for tissue regeneration, implantable sensors, and smart drug delivery, among others. Fabrication and testing of these materials using additive manufacturing technologies are of particular interest. Research is solicited that evaluates biological reactions to implant surface coatings as well as methods of depositing coating particles of varying size and composition. Release of molecules or particles from surfaces, either intentionally or due to wear and corrosion processes is also an area of interest.
D2 Invited Speaker:
- Holger Hoche, Technische Universität Darmstadt, Germany, “PVD Coatings to Control Corrosion Resistance of Mg Alloys”
D3. Biointerfaces: Coatings to Promote Cell Adhesion while Inhibiting Microbial Growth
Interaction between cells and biomaterials occurs via the surface characteristics of the material, which include their topography, chemistry, mechanical properties, or surface energy. These interactions trigger desired or undesired processes. For example, they can induce signaling pathways to regulate cell adhesion, migration, proliferation, and differentiation into specific phenotypes desirable for the application. However, they might also promote excessive adhesion of microorganisms forming biofilms that can lead to significant health risks. Such interactions are greatly determined by the initial protein adsorption that occurs in a shorter time scale. Understanding all these interaction processes and their correlation with the surface properties is key knowledge that will allow us to design novel surfaces or coatings to promote specific biological responses, i.e. design bioactive surfaces.
D3 Invited Speaker:
- Carles Corbella, The George Washington University, “Cold Atmospheric Plasma Jets Generated from Flexible Sources”
- Jessica DeBerardinis, Ultramet, “Chemical Vapor Deposition of Tantalum for Enhanced Cell Adhesion”